The Diagnosis and Management of Second-line Antiretroviral Treatment Failure

Published 22/04/2013
CPD credit available: 3

Disclosure of Financial Interests/Funding Support: Disclaimer: This case was presented as part of the HIV & TB Clinical Case Discussion satellite session at the Southern African Treatment and Resistance Network (SATuRN) workshop in Cape Town, 28 November 2012.


Case Objective: At the end of this case study, the reader should be able to interpret a genotypic resistance test in the context of the clinical history and demonstrate some understanding of resistance to second-line antiretroviral regimens that contain protease inhibitors. They should also be able to describe common adverse events on standard second-line antiretroviral regimens and to list some antiretroviral agents that could be used in third-line regimens.  


Instructions: This activity is an interactive learning activity and will give you an overview and detailed answers to the questions. Each case is separated into several sections, and only one section is visible at a time. Each section is concluded by a multiple choice question, where you will have to select the most appropriate answer. If this answer is not correct, you will be given the opportunity to re-select another answer.

After all the questions have been answered, there will be a post-test questionnaire in order to qualify for CPD points. Only users registered as members of the Southern African HIV Clinicians Society may obtain CPD points. If you are not a member and would like to join, please apply online.